Telomere length connects melanoma and glioma predispositions
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چکیده
منابع مشابه
Telomere Length and Aging
Telomeres, the TTAGGG tandem repeats at the ends of chromosomes, become progressively shortened with each replication of cultured human somatic cells (reviewed in Wong and Collins (Wong & Collins 2003)) until a critical length is achieved, at which point the cell enters replicative senescence. This situation can be reversed by the enzyme named telomerase that is responsible for Telomere Length ...
متن کاملAssociation between leukocyte telomere length and glioma risk: a case-control study.
BACKGROUND Compelling epidemiological evidence indicates that alterations of telomere length are associated with risks of many malignancies in a tumor-specific manner, such as lung cancer, breast cancer, and non-Hodgkin's lymphoma. However, the association between leukocyte telomere length and glioma risk has not been investigated. METHODS Relative telomere length (RTL) of peripheral blood le...
متن کاملLeukocyte telomere length: the telomere tale continues.
In culture, replicating human somatic cells display progressive telomere shortening. Ultimately, such cells either undergo apoptosis or enter a state of replicative senescence that is triggered by critically shortened telomeres. Accordingly, telomere length is an index of both the replicative history and the replicative potential of human somatic cells in culture (1). Most replicating human som...
متن کاملTelomere length and reproductive aging
BACKGROUND Rate of reproductive aging may be related to rate of biological aging. Thus, indicators of aging, such as short telomere length, may be more frequent in women with a history suggestive of premature reproductive senescence. METHODS Telomere-specific quantitative PCR was used to assess telomere length in two groups of women with evidence of reproductive aging: (i) patients with idiop...
متن کاملTelomere Length and the Risk of Cutaneous Malignant Melanoma in Melanoma-Prone Families with and without CDKN2A Mutations
INTRODUCTION Recent evidence suggests a link between constitutional telomere length (TL) and cancer risk. Previous studies have suggested that longer telomeres were associated with an increased risk of melanoma and larger size and number of nevi. The goal of this study was to examine whether TL modified the risk of melanoma in melanoma-prone families with and without CDKN2A germline mutations. ...
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ژورنال
عنوان ژورنال: Aging
سال: 2016
ISSN: 1945-4589
DOI: 10.18632/aging.100935